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Can I read Synthesis of Estromustine, Estramustine and Estramustine Phosphate Labelled with Deuterium on EtoBox?
Synthesis of Estromustine, Estramustine and Estramustine Phosphate Labelled with Deuterium by Danilo Giribone; Erminia Fontana is a Chemistry article available to read on EtoBox.
What is Synthesis of Estromustine, Estramustine and Estramustine Phosphate Labelled with Deuterium about?
The preparation of estromustine (EoM), estramustine (EaM) and estramustine phosphate (EMP) specifically labelled with deuterium is reported. A two-step, one-pot procedure based on the reaction of N,N-bis(2-chloroethyl)carbamoyl chloride with the commercially available [2,4,16, H 4 ]estrone (1) or [2,4,16,16, H 5 ]estradiol (2) afforded [2,4,16, H 4 ]estromustine (3) and [2,4,16,16, H 5 ]estramustine (4), respectively. The phosphorylation of 4 followed by hydrolysis gave [2,4,16,16, H 5 ]estramustine phosphate (5) in 65% chemical yield from 2.
Who reads Synthesis of Estromustine, Estramustine and Estramustine Phosphate Labelled with Deuterium?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Danilo Giribone; Erminia Fontana
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)
- Published
- 2004
- Language
- EN
- Field
- Chemistry (Life Sciences)