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Acute Remote Ischemic Preconditioning on a Rat Cremasteric Muscle Flap Model by Markus V. Küntscher; Thomas Kastell; Michael Sauerbier; Rainer Nobiling; Martha Maria Gebhard; Günter Germann is a Medicine article available to read on EtoBox.

What is Acute Remote Ischemic Preconditioning on a Rat Cremasteric Muscle Flap Model about?

## Abstract A previous study showed, in a rat adipocutaneous flap model, that acute ischemic preconditioning (IP) can be achieved not only by preclamping of the flap pedicle, but also by a brief extremity ischemia prior to flap ischemia. The purpose of this study was to determine whether remote IP is also effective in other tissues such as muscle flaps. Twenty male Wistar rats were divided into three experimental groups. The rat cremaster flap in vivo microscopy model was used for assessment of ischemia/reperfusion injury. In the control group (CG, n = 8), a 2‐hr flap ischemia was induced after preparation of the cremaster muscle. In the “classic” IP group (cIP, n = 6), a brief flap ischemia of 10 min was induced by preclamping the pedicle, followed by 30 min of reperfusion. A 10‐min ischemia of the contralateral hindlimb was induced in the remote IP group (rIP, n = 6). The limb was then reperfused for 30 min. Flap ischemia and the further experiment were performed as in the CG. In vivo microscopy was performed after 1 hr of flap reperfusion in each animal. A significantly higher red blood cell velocity in the first‐order arterioles and capillaries, a higher capillary flow, and a d

Who reads Acute Remote Ischemic Preconditioning on a Rat Cremasteric Muscle Flap Model?

Author

Markus V. Küntscher; Thomas Kastell; Michael Sauerbier; Rainer Nobiling; Martha Maria Gebhard; Günter Germann

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0738-1085)

Published

2002

Language

EN

Field

Medicine (Health Sciences)