Can I read Su520 POINT OF CARE ULTRASOUND IS A RELIABLE SCREENING TOOL AS COMPARED TO MAGNETIC RESONANCE ENTEROGRAPHY FOR ASSESSMENT OF THE TERMINAL ILEUM AND SIGMOID COLON IN PEDIATRIC PATIENTS WITH INFLAMMATORY BOWEL DISEASES on EtoBox?

Su520 POINT OF CARE ULTRASOUND IS A RELIABLE SCREENING TOOL AS COMPARED TO MAGNETIC RESONANCE ENTEROGRAPHY FOR ASSESSMENT OF THE TERMINAL ILEUM AND SIGMOID COLON IN PEDIATRIC PATIENTS WITH INFLAMMATORY BOWEL DISEASES by Mallory Chavannes; Jonathan Dillman; Araz Marachelian; D. Brent Polk is a Medicine article available to read on EtoBox.

What is Su520 POINT OF CARE ULTRASOUND IS A RELIABLE SCREENING TOOL AS COMPARED TO MAGNETIC RESONANCE ENTEROGRAPHY FOR ASSESSMENT OF THE TERMINAL ILEUM AND SIGMOID COLON IN PEDIATRIC PATIENTS WITH INFLAMMATORY BOWEL DISEASES about?

functional profiling was performed on 23/78 patients with baseline and post-induction (week14) stool samples. Kraken2 and Bracken were used to estimate species-level sequence abundances. Metacyc functional pathways were obtained using HUMAnN2. Clinical remission (CR) was defined as a wPCDAI <12.5, off steroids. Differential species and pathway abundances were evaluated for CL, IFX-levels, fecal calprotectin (FC) and wPCDAI scores using a linear model framework after log-ratio transformations. False discovery rate (FDR) corrections (< 0.1) were applied. Results: In this pilot study, median baseline FC was 1817 μg/g (IQR, 1469-2769) and CL 0.0104 L/h (0.0087-0.0133). By week14, 61% (14/23) had $50% improvement in FC, with 57% (13/23) in CR and a median IFX level of 7.7 μg/mL (2.4-11.5). 1SD increase in baseline CL was associated with 0.17 (-0.32; -0.02) reduction in Shannon diversity (p = 0.03). A log2 fold change for 27 baseline species were associated with a 1SD increase in Baseline CL (FDR 5% increase in CL at week14. FC and wPCDAI were not associated at an FDR <0.1 for any species or pathway examined. Conclusions: This pharmacomicrobiomics study demonstrates that diversity during

Who reads Su520 POINT OF CARE ULTRASOUND IS A RELIABLE SCREENING TOOL AS COMPARED TO MAGNETIC RESONANCE ENTEROGRAPHY FOR ASSESSMENT OF THE TERMINAL ILEUM AND SIGMOID COLON IN PEDIATRIC PATIENTS WITH INFLAMMATORY BOWEL DISEASES?

Author

Mallory Chavannes; Jonathan Dillman; Araz Marachelian; D. Brent Polk

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)