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Self-associated Indisulam in Phospholipid-based Nanomicelles: a Potential Nanomedicine for Cancer by Hacer Cesur; Israel Rubinstein; Ashwini Pai; Hayat Önyüksel is a Materials Science article available to read on EtoBox.

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This study aimed to begin development of a nanomedicine containing indisulam solubilized in sterically stabilized micelles (SSMs) composed of DSPE-PEG 2000 or sterically stabilized mixed micelles (SSMMs) composed of DSPE-PEG 2000 plus egg phosphatidylcholine. Micelles were prepared by co-precipitation and reconstitution of drug and lipids. Particle size distributions of micellar formulations were determined by quasi-elastic light scattering. Amounts of solubilized drug were determined by reverse-phase high-performance liquid chromatography (RP-HPLC). In vitro cytotoxicity of indisulam in nanocarrier was determined on the MCF-7 cell line by the National Cancer Institute-developed sulforhodamine B assay. Optimal solubilized indisulam concentrations in 5 mM total lipid were 10 μg/mL for SSMMs and 400 μg/mL for SSMs. HPLC results demonstrated that the encapsulation capacity of both micelles was over 95%. In vitro studies showed that indisulam in micellar system was more effective than free indisulam. The optimized formulation was successfully freeze-dried without any addition of lyoprotectants or cryoprotectants. We conclude that SSMs are a promising nanocarrier for indisulam, and indi

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Author

Hacer Cesur; Israel Rubinstein; Ashwini Pai; Hayat Önyüksel

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1549-9634)

Published

2009

Language

EN

Field

Materials Science (Physical Sciences)