Can I read Encapsulation of Thiabendazole in Hydroxypropyl‐ β ‐Cyclodextrin Nanofibers via Polymer‐free Electrospinning and Its Characterization on EtoBox?

Encapsulation of Thiabendazole in Hydroxypropyl‐ β ‐Cyclodextrin Nanofibers via Polymer‐free Electrospinning and Its Characterization by Shuang Gao; Yanyan Liu; Jingyu Jiang; Xiaoming Li; Lixia Zhao; Ying Fu; Fei Ye is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Encapsulation of Thiabendazole in Hydroxypropyl‐ β ‐Cyclodextrin Nanofibers via Polymer‐free Electrospinning and Its Characterization about?

## Abstract ## BACKGROUND Thiabendazole (TBZ) is a poorly water‐soluble benzimidazole fungicide. However, the water solubility of TBZ can be significantly enhanced by inclusion complexation with cyclodextrins. In this study, a thiabendazole/hydroxypropyl‐β‐cyclodextrin (TBZ/HPβCD) complex was synthesized and electrospinning was performed to produce a TBZ/HPβCD nanofibrous (TBZ/HPβCD‐NF) complex that improved water solubility and antifungal activity. ## RESULTS The formation of TBZ/HPβCD‐NF was characterized by Fourier transform infrared spectroscopy, X‐ray diffraction and nuclear magnetic resonance. The morphology of TBZ/HPβCD‐NF was studied by scanning electron microscopy. A phase solubility experiment showed that HPβCD exerted a great solubilization effect on TBZ, and TBZ/HPβCD‐NF had better antifungal activity compared to that of TBZ alone. ## CONCLUSIONS In summary, the solid fungicidal nanodispersion prepared in the present study is a new type of formulation that can enhance the water solubility of TBZ. This formulation, which demonstrated potential as a new fast dissolving formulation type with increased efficacy, is expected to be conducive to the sustainable development of

Who reads Encapsulation of Thiabendazole in Hydroxypropyl‐ β ‐Cyclodextrin Nanofibers via Polymer‐free Electrospinning and Its Characterization?

Author

Shuang Gao; Yanyan Liu; Jingyu Jiang; Xiaoming Li; Lixia Zhao; Ying Fu; Fei Ye

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1526-498X)

Published

2020

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)