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Can I read Polymer-Conjugated Carbon Nanotubes for Biomolecule Loading on EtoBox?
Polymer-Conjugated Carbon Nanotubes for Biomolecule Loading by Christopher T. Jackson; Jeffrey W. Wang; Eduardo González-Grandío; Natalie S. Goh; Jaewan Mun; Sejal Krishnan; Florian Ludwig Geyer; Harald Keller; Sophia Ebert; Kian Molawi; Nadine Kaiser; Markita P. Landry is a Engineering article available to read on EtoBox.
What is Polymer-Conjugated Carbon Nanotubes for Biomolecule Loading about?
Nanomaterials have emerged as an invaluable tool for the delivery of biomolecules such as DNA and RNA, with various applications in genetic engineering and post-transcriptional genetic manipulation. Alongside this development, there has been an increasing use of polymer-based techniques, such as polyethylenimine (PEI), to electrostatically load polynucleotide cargoes onto nanomaterial carriers. However, there remains a need to assess nanomaterial properties, conjugation conditions, and biocompatibility of these nanomaterial-polymer constructs, particularly for use in plant systems. In this work, we develop mechanisms to optimize DNA loading on singlewalled carbon nanotubes (SWNTs) with a library of polymer-SWNT constructs and assess DNA loading ability, polydispersity, and both chemical and colloidal stability. Counterintuitively, we demonstrate that polymer hydrolysis from nanomaterial surfaces can occur depending on polymer properties and attachment chemistries, and we describe mitigation strategies against construct degradation. Given the growing interest in delivery applications in plant systems, we also assess the stress response of plants to polymer-based nanomaterials and pr
Who reads Polymer-Conjugated Carbon Nanotubes for Biomolecule Loading?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Christopher T. Jackson; Jeffrey W. Wang; Eduardo González-Grandío; Natalie S. Goh; Jaewan Mun; Sejal Krishnan; Florian Ludwig Geyer; Harald Keller; Sophia Ebert; Kian Molawi; Nadine Kaiser; Markita P. Landry
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)