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Effects of Anticholinesterase Reversal Under General Anesthesia on Postoperative Cardiovascular Complications: A Retrospective Cohort Study by Shaydenfish, Denys; Scheffenbichler, Flora T.; Kelly, Barry J.; Lihn, Anne-Louise; Deng, Hao; Nourmahnad, Anahita; Xu, Xinling; Houle, Timothy T.; Eikermann, Matthias; Forman, Stuart A. is a Medicine article available to read on EtoBox.
What is Effects of Anticholinesterase Reversal Under General Anesthesia on Postoperative Cardiovascular Complications: A Retrospective Cohort Study about?
## Background: The anticholinesterase neostigmine and the muscarinic inhibitor glycopyrrolate are frequently coadministered for the reversal of neuromuscular blockade. this practice can precipitate severe bradycardia or tachycardia, but whether it affects the incidence of cardiovascular complications remains unclear. we hypothesized that anticholinesterase reversal with neostigmine and glycopyrrolate versus no anticholinesterase reversal increases the risk of postoperative cardiovascular complications among adult patients undergoing noncardiac surgery with general anesthesia. ## Methods: We conducted a prespecified retrospective analysis of hospital registry data from a major health care network for patients undergoing surgery with general anesthesia from january 2007 to december 2015. the primary outcome was a composite of cardiac dysrhythmia, acute heart failure, transient ischemic attack, ischemic stroke, and acute myocardial infarction within 30 days after surgery. we performed sensitivity analyses in subgroups and propensity score adjustment and explored the association between exposure and outcome in subgroups of patients with high risk of cardiovascular complications. ## Res
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- Author
- Shaydenfish, Denys; Scheffenbichler, Flora T.; Kelly, Barry J.; Lihn, Anne-Louise; Deng, Hao; Nourmahnad, Anahita; Xu, Xinling; Houle, Timothy T.; Eikermann, Matthias; Forman, Stuart A.
- Publisher
- Lippincott Williams and Wilkins; Ovid Technologies (Wolters Kluwer) - Anesthesia & Analgesia; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 0003-2999)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)