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Can I read Water extracts of Tibetan medicine Wuweiganlu attenuates experimental arthritis via inducing macrophage polarization towards the M2 type on EtoBox?
Water extracts of Tibetan medicine Wuweiganlu attenuates experimental arthritis via inducing macrophage polarization towards the M2 type by Yuanyuan Wen; Shijie Zhang; Xinyu Meng; Chenyang Zhao; Bao Hou; Xuexue Zhu; Weiwei Cai; Yuetao Zhou; Liying Qiu; Haijian Sun is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Water extracts of Tibetan medicine Wuweiganlu attenuates experimental arthritis via inducing macrophage polarization towards the M2 type about?
Ethnopharmacological relevance: Wuweiganlu (WGL) is a well-known formulation described in the "Four Medical Scriptures of Tibetan medicine", which is mainly used for the treatment of Rheumatoid Arthritis (RA) and other chronic ailments prescribed by Tibetan medicine. Nonetheless, the active constituents present in the water extracts of Wuweiganlu (WGLWE) specifically targeting arthritis treatment are largely unknown. Aim of the study: The aim of this study is to explore the effects and underlying mechanisms of the active components in WGLWE on RA. Materials and methods: We utilized ultra-performance liquid chromatography coupled with Q-TOF mass spectrometry (UPLC-Q-TOF-MS) to identify the main chemical compositions of WGLWE. The polarization effect of WGLWE on bone marrow-derived macrophages (BMDM) was determined. A rat model of collagen-induced arthritis (CIA) was established by injecting an emulsion of bovine type II collagen mixed with an equal volume of incomplete Freund's adjuvant into the tail, paw and back of rats. A WGLWE-based ointment was topically applied to the legs and paws of the rats for 30 days. The rats' ankles were photographed to measure the degree of swelling. M
Who reads Water extracts of Tibetan medicine Wuweiganlu attenuates experimental arthritis via inducing macrophage polarization towards the M2 type?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Yuanyuan Wen; Shijie Zhang; Xinyu Meng; Chenyang Zhao; Bao Hou; Xuexue Zhu; Weiwei Cai; Yuetao Zhou; Liying Qiu; Haijian Sun
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)