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Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines 4 Preface 6 Contents 8 Contributors 10 Chapter 1: Immunomic Discovery of Adjuvants, Delivery Systems, and Candidate Subunit Vaccines: A Brief Introduction 12 Chapter 2: Bacterial Genomes and Vaccine Design 23 Chapter 3: Identification of Candidate Vaccine Antigens In Silico 48 Chapter 4: Post-genomic Antigen Discovery: Bioinformatical Approaches to Reveal Novel T Cell Antigens of Mycobacterium bovis 81 Chapter 5: Genome-Based Computational Vaccine Discovery by Reverse Vaccinology 99 Chapter 6: Computational Prediction of Protein Subcellular Localization, Genomic Islands, and Virulence to Aid Antigen Discovery 113 Chapter 7: On the Development of Vaccine Antigen Databases: Progress, Opportunity, and Challenge 124 Chapter 8: What Have Dendritic Cells Ever Done for Adjuvant Design? Cellular and Molecular Methods for the Rational Development of Vaccine Adjuvants 138 Chapter 9: Towards the Systematic Discovery of Immunomodulatory Adjuvants 162 Chapter 10: Designing Liposomes as Vaccine Adjuvants 188 Chapter 11: Designing Nonionic Surfactant Vesicles for the Delivery of Antigens for Systemic and Alternative Delivery Routes

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