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Synthesis, characterization and DNA binding of ruthenim(II) complexes containing the atatp ligand by Qi-Xiong Zhen; Qian-Ling Zhang; Jin-Gang Liu; Bao-Hui Ye; Liang-Nian Ji; Lei Wang is a Chemistry article available to read on EtoBox.

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Acenaphtheno[1,2-b]-1,4,8,9-tetraazatriphenylene (atatp) and its complexes [Ru(L) 2 atatp](ClO 4 ) 2 PnH 2 O (Ls2,29-bipyridine (bpy), ns2 (1); 1,10-phenanthroline (phen), ns2 (2); and 2,9-dimethyl-1,10-phenanthroline (dmp), ns1 (3)) have been synthesized and characterized by elemental analyses and 1 H NMR. The spectral and electrochemical properties of these complexes are also examined. Complexes 1 and 2 display bright luminescence in acetonitrile but very weak luminescence in water solution. However, complex 3 is not luminescent in either solvent. The interaction of the complexes with calf thymus DNA (CT-DNA) has been studied by absorption, emission and viscosity measurements. The intrinsic binding constants of complexes 1 and 2 are 7.6=10 4 and 8.8=10 4 M y1 respectively. The relatively low affinities of complexes 1 and 2 with DNA may arise from the atatp ligand, indicating that the size and shape of the intercalated ligand have a marked effect on the strength of interaction. Complexes 1 and 2 bind with CT-DNA in an intercalative mode but complex 3 in a nonintercalative one, showing that changing the ancillary ligand affects not only the binding magnitude, but also the binding m

Who reads Synthesis, characterization and DNA binding of ruthenim(II) complexes containing the atatp ligand?

Author

Qi-Xiong Zhen; Qian-Ling Zhang; Jin-Gang Liu; Bao-Hui Ye; Liang-Nian Ji; Lei Wang

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0162-0134)

Published

2000

Language

EN

Field

Chemistry (Physical Sciences)