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Apoptotic and Behavioral Sequelae of Mild Brain Trauma in Mice by David Tweedie; Anat Milman; Harold W. Holloway; Yazhou Li; Brandon K. Harvey; Hui Shen; Paul J. Pistell; Debomoy K. Lahiri; Barry J. Hoffer; Yun Wang; Chaim G. Pick; Nigel H. Greig is a Neuroscience article available to read on EtoBox.

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## Abstract Mild traumatic brain injury (mTBI) is a not uncommon event in adolescents and young adults. Although it does not result in clear morphological brain defects, it is associated with long‐term cognitive, emotional, and behavioral problems. Herein, we characterized the biochemical and behavioral changes associated with experimental mTBI in mice that may act as either targets or surrogate markers for interventional therapy. Specifically, mTBI was induced by 30‐g and 50‐g weight drop, and at 8 and 72 hr thereafter markers of cellular apoptosis—caspase‐3, Bax, apoptosis‐inducing factor (AIF), and cytochrome‐c (Cyt‐c)—were quantified by Western blot analysis in hippocampus ipsilateral to the impact. Levels of amyloid‐β precursor protein (APP) were also measured, and specific behavioral tests—passive avoidance, open field, and forced swimming (Porsolt) paradigms—were undertaken to assess learning, emotionality, and emotional memory. In the absence of hemorrhage or infarcts, as assessed by triphenyltetrazolium chloride staining, procaspase‐3 and Bax levels were markedly altered following mTBI at both times. No cleaved caspase‐3 was detected, and levels of AIF and Cyt‐c, but not A

Who reads Apoptotic and Behavioral Sequelae of Mild Brain Trauma in Mice?

Author

David Tweedie; Anat Milman; Harold W. Holloway; Yazhou Li; Brandon K. Harvey; Hui Shen; Paul J. Pistell; Debomoy K. Lahiri; Barry J. Hoffer; Yun Wang; Chaim G. Pick; Nigel H. Greig

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

2007

Language

EN

Field

Neuroscience (Life Sciences)