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Can I read Applicability of Vericiguat to Patients Hospitalized for Heart Failure in the United States on EtoBox?
Applicability of Vericiguat to Patients Hospitalized for Heart Failure in the United States by Muhammad Shahzeb Khan; Haolin Xu; Gregg C. Fonarow; Dominik Lautsch; Robert Hilkert; Larry A. Allen; Adam D. DeVore; Brooke Alhanti; Clyde W. Yancy; Nancy M. Albert; Javed Butler; Stephen J. Greene is a Medicine article available to read on EtoBox.
What is Applicability of Vericiguat to Patients Hospitalized for Heart Failure in the United States about?
Background In January 2021, vericiguat, a soluble guanylate cyclase stimulator, was approved by the U.S. Food and Drug Administration (FDA) to reduce the risk of cardiovascular death and heart failure (HF) hospitalization among patients with a recent worsening HF event based on the VICTORIA (VerICiguaT Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial. Objectives This study sought to leverage a contemporary U.S. registry of patients hospitalized for heart failure (HF) to characterize patients who may be candidates for vericiguat based on FDA label and the VICTORIA trial eligibility criteria. Methods The authors studied patients hospitalized for HF with ejection fraction (EF) <45% across 525 sites in the GWTG-HF (Get With The Guidelines–Heart Failure) registry between January 2014 and December 2020. Approximate FDA label criteria (excluding estimated glomerular filtration rate [eGFR] <15 mL/min/1.73 m2, dialysis, or patients with heart transplantation or durable mechanical circulatory support) and eligibility criteria for the VICTORIA trial were applied to the GWTG-HF cohort. Results Among 241,057 patients with EF <45% in the GWTG-HF registry, 221,730
Who reads Applicability of Vericiguat to Patients Hospitalized for Heart Failure in the United States?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Muhammad Shahzeb Khan; Haolin Xu; Gregg C. Fonarow; Dominik Lautsch; Robert Hilkert; Larry A. Allen; Adam D. DeVore; Brooke Alhanti; Clyde W. Yancy; Nancy M. Albert; Javed Butler; Stephen J. Greene
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)