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Can I read Vasculature Deprivation – Induced Osteonecrosis of the Rat Femoral Head as a Model for Therapeutic Trials on EtoBox?
Vasculature Deprivation – Induced Osteonecrosis of the Rat Femoral Head as a Model for Therapeutic Trials by Jacob Bejar; Eli Peled; Jochanan H Boss is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Vasculature Deprivation – Induced Osteonecrosis of the Rat Femoral Head as a Model for Therapeutic Trials about?
## Experimental Osteonecrosis The authors' experience with experimentally produced femoral capital osteonecrosis in rats is reviewed: incising the periosteum at the base of the neck of the femur and cutting the ligamentum teres leads to coagulation necrosis of the epiphysis. The necrotic debris is substituted by fibrous tissue concomitantly with resorption of the dead soft and hard tissues by macrophages and osteoclasts, respectively. Progressively, the formerly necrotic epiphysis is repopulated by hematopoietic-fatty tissue, and replaced by architecturally abnormal and biomechanically weak bone. The femoral heads lose their smooth-surfaced hemispherical shape in the wake of the load transfer through the hip joint such that, together with regressive changes of the joint cartilage and inflammatory-hyperplastic changes of the articular membrane, an osteoarthritis-like disorder ensues. ## Therapeutic Choices Diverse therapeutic options are studied to satisfy the different opinions concerning the significance of diverse etiological and pathogenic mechanisms: 1. Exposure to hyperbaric oxygen. 2. Exposure to hyperbaric oxygen and non-weight bearing on the operated hip. 3. Medication with
Who reads Vasculature Deprivation – Induced Osteonecrosis of the Rat Femoral Head as a Model for Therapeutic Trials?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jacob Bejar; Eli Peled; Jochanan H Boss
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2004-; Springer Science and Business Media LLC (ISSN 1742-4682)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)