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Characterization of overt and occult hepatitis B virus infection among HTLV-1 positive healthy carriers in the Northeast of Iran; An HTLV-I endemic area: Characterization of Overt and Occult Hepatitis B in HTLV-1 Positive Patients by Maryam Chenari; Mehdy Norouzi; Leila Ghalichi; Abdolrahim Rezaee; Atefe Yari; Seyed Moayed Alavian; Seyed Mohammad Jazayeri is a Medicine article available to read on EtoBox.

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To date, no studies have provided data on hepatitis B virus (HBV) prevalence among asymptomatic, healthy human T-lymphotropic virus (HTLV-I) positive carriers. This sero- and molecular epidemiology study was performed on patients in the Northeast of Iran, which is an endemic area for HTLV-I infection. A total of 109 sera were collected from HTLV-I positive healthy carriers who were admitted to Ghaem Hospital, Mashhad City. All were tested for HBV serology and subsequently, real time PCR was carried out on the samples, regardless of the results of the serology. Standard PCR and direct sequencing were applied on positive samples. All cases were negative for HBsAg, Anti-HBc, and anti-HBs were positive in 34 (31.1%), and 35 (32%) individuals, respectively. There were 19 (17.4%) cases that were positive only for anti-HBs, and they had already received HBV vaccine. 16 (15%) were positive for both anti-HBs and anti-HBc, indicating a past-resolved HBV infection. 18 (16.5%) were isolated as anti-HBc, and 56 (51.3%) were negative for all HBV serological markers. Only one subject (0.9%) had detectable HBV DNA (2153 copy/ml), and assigned as being an occult HBV infection. The low prevalence of

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Author

Maryam Chenari; Mehdy Norouzi; Leila Ghalichi; Abdolrahim Rezaee; Atefe Yari; Seyed Moayed Alavian; Seyed Mohammad Jazayeri

Publisher

Wiley

Published

2014

Language

EN

Field

Medicine (Health Sciences)