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Can I read Absolute Bioavailability of Letrozole in Healthy Postmenopausal Women on EtoBox?
Absolute Bioavailability of Letrozole in Healthy Postmenopausal Women by A. Sioufi; N. Gauducheau; V. Pineau; F. Marfil; A. Jaouen; J. M. Cardot; J. Godbillon; C. Czendlik; H. Howald; CH. Pfister; F. Vreeland is a Medicine article available to read on EtoBox.
What is Absolute Bioavailability of Letrozole in Healthy Postmenopausal Women about?
Letrozole is a new non-steroidal inhibitor of the aromatase enzyme system. It is currently under development for the treatment of postmenopausal women with advanced breast cancer. Absolute bioavailability of letrozole when given orally as one 2 ́5 mg ®lm-coated tablet in comparison to the same dose given intravenously as a bolus injection was studied in 12 healthy postmenopausal women. Letrozole absolute systemic bioavailability after p.o. administration was 99 ́9+16 ́3%. Elimination of letrozole was slow. Total-body clearance of letrozole from plasma after i.v. administration was low (2.21 L h 71 ). The calculated distribution volume at steady state (1.87 L kg 71 ) suggests a rather high tissue distribution. Biotransformation of letrozole is the main elimination mechanism with the glucuronide conjugate of the secondary alcohol metabolite being the predominant species found in urine. The two study treatments were tolerated equally well. &1997 John Wiley & Sons, Ltd.
Who reads Absolute Bioavailability of Letrozole in Healthy Postmenopausal Women?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- A. Sioufi; N. Gauducheau; V. Pineau; F. Marfil; A. Jaouen; J. M. Cardot; J. Godbillon; C. Czendlik; H. Howald; CH. Pfister; F. Vreeland
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0142-2782)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)