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Immune Checkpoints Pathways in Head and Neck Squamous Cell Carcinoma by Veigas, Florencia (author);Mahmoud, Yamil D. (author);Merlo, Joaquin (author);Rinflerch, Adriana (author);Rabinovich, Gabriel Adrian (author);Girotti, María Romina (author) is a Medicine article available to read on EtoBox.

What is Immune Checkpoints Pathways in Head and Neck Squamous Cell Carcinoma about?

Simple Summary: During the last decades, scientific advances in immuno-oncology and a better understanding of tumors' immune profile led to the development of novel immunotherapeutic strategies, especially immune checkpoint inhibitors. The blockade of PD-1 by monoclonal antibodies (mAbs) is the only immunotherapy based on immune checkpoint pathways approved for head and neck squamous cell carcinoma. As only a small fraction of patients perceives clinical benefit, understanding the molecular mechanisms and signaling pathways activated by the immune checkpoints and other tumor intrinsic features that modulate the immune infiltrate is crucial to better select patients for immunotherapy treatment and to develop novel therapeutic strategies. We here review the immune escape mechanisms of head and neck tumors, with a particular focus on the immune checkpoints, their role as therapeutic targets, and the predictive biomarkers of response to anti-PD-1/PD-L1 therapy. We also summarize the ongoing clinical trials testing several combinations of immune checkpoint inhibitors with other therapeutic approaches to improve patient outcomes. Abstract: Head and neck squamous cell carcinoma (HNSCC) is

Who reads Immune Checkpoints Pathways in Head and Neck Squamous Cell Carcinoma?

Author

Veigas, Florencia (author);Mahmoud, Yamil D. (author);Merlo, Joaquin (author);Rinflerch, Adriana (author);Rabinovich, Gabriel Adrian (author);Girotti, María Romina (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)