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This article discusses the design and synthesis of bitopic arylpiperazine-phthalimides as selective dopamine D3 receptor agonists, which are important for treating neurological disorders while minimizing side effects associated with dopamine D2 receptor antagonism. The study identifies compound 9i as the most selective D3R ligand, demonstrating significant improvements in potency and selectivity compared to existing compounds. The findings highlight the potential of fragment-based design and molecular docki

Author

ningsun113

Language

EN