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The Interaction of Nitric Oxide and Prostaglandins in the Control of Corporal Smooth Muscle Tone: Evidence for Production of a Cyclooxygenase-derived Endothelium-contracting Factor by S. Minhas; J.J. Cartledge; I. Eardley; A.D. Joyce; J.F.B. Morrison is a Medicine article available to read on EtoBox.

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## Objective: To investigate the interaction of endothelium-derived nitric oxide (no) and prostaglandins (pgs) in regulating corporal smooth muscle tone in vitro. materials and methods strips of rabbit corpus cavernosum were mounted in organ chambers for the measurement of isometric tension. strips were submaximally contracted with noradrenaline and concentration-response curves (crcs) to acetylcholine (ach) were constructed before and after treatment with 5 micromol/l atropine, 20 micromol of the cyclooxygenase inhibitor indomethacin and 10 micromol of the pgh2/thromboxane a2 receptor antagonist sq29548. the no synthase (nos) inhibitors l-ng-monomethyl arginine (l-nmma) and l-ng-nitroarginine (l-noarg) were added to strips at tonic tension in the presence and absence of indomethacin, and after this crcs to ach were constructed. ## Results: The addition of ach to strips produced a concentration-dependent relaxation which was inhibited by atropine. indomethacin, but not sq29548, significantly increased relaxation to ach. relaxation to ach was impaired by l-nmma, but adding ach to strips treated with l-noarg resulted in contractile responses, whilst both effects were reversed by indo

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Author

S. Minhas; J.J. Cartledge; I. Eardley; A.D. Joyce; J.F.B. Morrison

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1464-4096)

Published

2002

Language

EN

Field

Medicine (Health Sciences)