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Risk mapping of lung cancer: a comprehensive appraisal of published meta-analyses incorporating Mendelian randomization studies by Caichen Li; Jianfu Li; Shan Xiong; Huaqiang Zhou; Xiuyu Cai; Zhanhong Xie; Haoxin Peng; Xiangrong Wu; Ran Zhong; Yu Jiang; Zixuan Su; Feng Zhu; Zhenyu Huo; Bo Liu; Wenhao Chi; Huiting Wang; Yaokai Wen; Fan Ge; Yi Feng; Runchen Wang; Jiana Chen; Zisheng Chen; Jiang Shi; Bo Cheng; Zhuxing Chen; Hengrui Liang; Feng Li; Hongsheng Deng; Jianxing He; Wenhua Liang is a Medicine article available to read on EtoBox.

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Introduction A comprehensive appraisal of published meta-analyses incorporating Mendelian randomization studies was performed to map the different risk factors and assess the causality for lung cancer. Methods Systematic reviews and meta-analyses of observational and interventional studies were reviewed based on PubMed, Embase, Web of Science, and Cochrane Library. Mendelian randomization analyses were conducted to validate the causal associations of those various exposures with lung cancer using summary statistics from 10 genome-wide association studies (GWAS) consortia and other GWAS databases in MR-Base platform. Results In the review of meta-analyses, 105 risk factors associated with lung cancer were identified from 93 articles. It was found that 72 risk factors were nominally significant (P < 0.05) associated with lung cancer. Mendelian randomization analyses were performed to analyze 36 exposures based on 551 SNPs and 4,944,052 individuals, finding that 3 exposures had a consistent risk/protective effect on lung cancer with the results of the meta-analysis. In Mendelian randomization anaylses, smoking (OR 1.44, 95% CI 1.18-1.75; P = 0.001) and blood copper (OR 1.14, 95% CI 1.

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Author

Caichen Li; Jianfu Li; Shan Xiong; Huaqiang Zhou; Xiuyu Cai; Zhanhong Xie; Haoxin Peng; Xiangrong Wu; Ran Zhong; Yu Jiang; Zixuan Su; Feng Zhu; Zhenyu Huo; Bo Liu; Wenhao Chi; Huiting Wang; Yaokai Wen; Fan Ge; Yi Feng; Runchen Wang; Jiana Chen; Zisheng Chen; Jiang Shi; Bo Cheng; Zhuxing Chen; Hengrui Liang; Feng Li; Hongsheng Deng; Jianxing He; Wenhua Liang

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)