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Myelin Lipid Metabolism and Its Role in Myelination and Myelin Maintenance by Joseph A. Barnes-Vélez; Fatma Betul Aksoy Yasar; Jian Hu is a Environmental Science article available to read on EtoBox.

What is Myelin Lipid Metabolism and Its Role in Myelination and Myelin Maintenance about?

Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin’s salient features that contribute to its unique role as an insulator that electrically isolates nerve fibers across their myelinated surface. The most abundant lipids in myelin include cholesterol, glycosphingolipids, and plasmalogens, each playing critical roles in myelin development as well as function. This review serves to summarize the role of lipid metabolism in myelination and myelin maintenance, as well as the molecular determinants of myelin lipid homeostasis, with an emphasis on findings from genetic models. In addition, the implications of myelin lipid dysmetabolism in human diseases are highlighted in the context of hereditary leukodystrophies and neuropathies as well as acquired disorders such as Alzheimer’s disease.

Who reads Myelin Lipid Metabolism and Its Role in Myelination and Myelin Maintenance?

Author

Joseph A. Barnes-Vélez; Fatma Betul Aksoy Yasar; Jian Hu

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Environmental Science (Physical Sciences)