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Cortical activation and functional connectivity during the verbal fluency task for adolescent-onset depression: A multi-channel NIRS study by Xiaoli Liu; Fang Cheng; Shasha Hu; Beini Wang; Changzhou Hu; Zhenzhen Zhu; Wenhao Zhuang; Xi Mei; Xingxing Li; Qi Zhou; Wenwu Zhang; Yiping Tang; Dongsheng Zhou is a Psychology article available to read on EtoBox.

What is Cortical activation and functional connectivity during the verbal fluency task for adolescent-onset depression: A multi-channel NIRS study about?

## Objective: Depression disorder is accompanied by cognitive impairments. however, there is limited research focused on cognitive impairments and their neurological mechanism in adolescents with depression. the purpose of the current study is to illustrate the differences in brain activity patterns between depressed adolescents and healthy controls (hcs). ## Method: A total of 72 adolescents with depression, as well as 74 hcs, were recruited. we utilized functional near-infrared spectroscopy (fnirs) to monitor the concentrations of oxyhemoglobin (oxy-hb) in the brains of participants while they performed the verbal fluency task (vft) to examine cognitive impairment in adolescents with depression. ## Results: Our study demonstrated that adolescents with depression had significantly less cortical activation in the hemodynamic responses of oxy-hb at channels mainly located in the prefrontal cortex (pfc) than hcs during the 60-s task period (false discovery rate (fdr)-corrected p < 0.05). the mean channel-to-channel connectivity was 0.400 for hcs (sd = 0.149) and 0.303 (sd = 0.138) for adolescents with depression, and the hc group had a higher mean channel-to-channel connectivity stre

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Author
Xiaoli Liu; Fang Cheng; Shasha Hu; Beini Wang; Changzhou Hu; Zhenzhen Zhu; Wenhao Zhuang; Xi Mei; Xingxing Li; Qi Zhou; Wenwu Zhang; Yiping Tang; Dongsheng Zhou
Publisher
Elsevier BV
Published
2022
Language
EN
Field
Psychology (Social Sciences)

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