Can I read Divergent structure and function of the bicoid gene in Muscoidea fly species on EtoBox?

Divergent structure and function of the bicoid gene in Muscoidea fly species by Philip J. Shaw; Ahmad Salameh; Alistair P. McGregor; Sendu Bala; Gabriel A. Dover is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Divergent structure and function of the bicoid gene in Muscoidea fly species about?

**SUMMARY** We have investigated the evolution of the __bicoid__ (__bcd__) gene in fly species of the Muscoidea Superfamily. We obtained the complete __bcd__ sequence from the housefly __Musca domestica__ and found polymorphism in the coding region among __Musca__ strains. In addition to __Musca__, we cloned most of the __bcd__ coding sequences from two blowfly species __Calliphora vicina__ and __Lucilia sericata__. The 5′ and 3′ regulatory regions flanking the __Musca bcd__ gene are widely diverged in sequence from __Drosophila;__ however, some important sequence motifs identified in __Drosophila bcd__ are present. The predicted RNA secondary structures of the 3′ UTRs are similar, despite sequence divergence. Comparison of Bicoid (Bcd) proteins shows a serine‐rich domain of unknown function is present in the Muscoidea species, but is absent in other species. The in vivo function of __bcd__ in __Musca__ was tested by RNAi to mimic loss of function phenotype. We obtained a head defect phenotype similar to weak __bcd__ alleles of __Drosophila__. Although our comparisons initially suggest functional conservation between species, closer inspection reveals significant differences. Diver

Who reads Divergent structure and function of the bicoid gene in Muscoidea fly species?

Author

Philip J. Shaw; Ahmad Salameh; Alistair P. McGregor; Sendu Bala; Gabriel A. Dover

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1520-541X)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)