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Placental Transfer and Fetal Uptake of Amino Acids in the Pregnant Ewe by Maureen Young; I. R. Mc. Fadyen is a Medicine article available to read on EtoBox.

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Analysis of fetal carcass protein, from the calf (JACOBSEN et al. [16]) and rat (SOUTHGATE [34]), has shown that the amino acids are the same, and present in the same proportions, äs in weanling and adult protein (WILLIAMS etal. [37]). N This indicates that all the amino acids are probably transferred across the placental barrier, because it is known that the enzymes converting essential to non-essential amino acids are not always active in fetal liver until after birth (JAKUBOVIC [17], and GAULL et al. [8]). Experimental evidence for this transfer has been obtained in the guinea pig with the fetal placenta perfused c in situ'; each essential amino acid, with the exception of threonine and tryptophan, and the majority of non-essential amino acids, were shown to be transported from the maternal plasma, across the placental membrane against a concentration gradient (YouNG and HILL [37]): It is a well known fact that the free amino concentration in maternal plasma is low during gestation, at a time when it might be expected to be maintained to ensure a fetal supply. The purpose of the present study was to observe the influence of an increase in the concentration of the free amino acid

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Author

Maureen Young; I. R. Mc. Fadyen

Publisher

Walter de Gruyter GmbH

Published

1973

Language

EN

Field

Medicine (Health Sciences)