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Serum Immunoinflammation-related Protein Complexes Discriminate Between Inflammatory Bowel Disease and Colorectal Cancer by Sun, Y. H.; Li, J.; Shu, H. J.; Li, Z. L.; Qian, J. M. is a Medicine article available to read on EtoBox.

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## Purpose: Inflammatory bowel disease (ibd) is an important risk factor for colon cancer. novel serum immunoinflammation-related protein complexes (iirpcs) have shown associations with early cancer detection. herein, we investigated the potential of serum iirpcs for discriminating between ibd and colorectal cancer (crc) patients. ## Methods: Serum protein complexes of 65 healthy controls, 57 crc, 69 (ulcerative colitis) uc, and 67 (crohn's disease) cd patients were isolated by native-page. the gray values of serum iirpcs bands in the gel were quantified using quantity one software. the receiver-operating characteristic (roc) curves were constructed to assess the discriminating ability by calculating the area under the roc curve. ## Results: The serum iirpcs levels in ibd and crc patients were significantly elevated compared to healthy controls. roc analysis indicated certain diagnostic ability of serum iirpcs in differentiating ibd from crc. specifically, "a3" complex discriminated uc from crc, with an auc value of 0.722, sensitivity of 69.4% and specificity of 63.8%. similarly, "b4" complex discriminated uc from crc, with an auc value of 0.709, sensitivity of 70.4%, and specifici

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Author

Sun, Y. H.; Li, J.; Shu, H. J.; Li, Z. L.; Qian, J. M.

Publisher

Springer Milan; Springer-Verlag; Springer-Verlag Italia; Springer Science and Business Media LLC (ISSN 1699-048X)

Published

2019

Language

EN

Field

Medicine (Health Sciences)