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Influence of Quillaja saponaria Triterpenoid Content on the Immunomodulatory Capacity of Epstein–Barr Virus Iscoms by E. DOTSIKA; E. KARAGOUNI; B. SUNDQUIST; B. MOREIN; A. MORGAN; M. VILLACRES-ERIKSSON is a Immunology and Microbiology article available to read on EtoBox.

What is Influence of Quillaja saponaria Triterpenoid Content on the Immunomodulatory Capacity of Epstein–Barr Virus Iscoms about?

The immune responses to immunostimulating complexes (iscoms) containing recombinant Epstein–Barr virus (EBV) gp340 envelope protein was evaluated in BALB/c (H‐2^d^) and CBA (H‐2^k^) mice. Gp340‐iscoms were used either with a low content of __Quillaja__ triterpenoid adjuvant (L‐iscoms) or supplemented with additional __Quillaja__ adjuvant in the form of iscomatrix (S‐iscoms). Class and subclass distribution of anti‐gp340 antibodies, EBV‐neutralizing antibodies, antigen‐specific T cell proliferation and cytokine production were determined and these results compared to those obtained by immunization with non‐adjuvated gp340. The H‐2^d^ and H‐2^k^ mice were characterized as low or high responders in respect to the level of specific anti‐gp340 antibodies, secretion of IgG2a isotype, antigen‐specific lymphoproliferative capacity, interferon‐γ (IFN‐γ) and interleukin‐10 (IL‐10) production in the basic immunizations with gp340. While presentation of the antigen in iscom formulations with low levels of __Quillaja__ triterpenoids induces a moderate enhancement of the immune responses in the low responder H‐2^d^ mice, supplementation with high levels of iscomatrix immunomodulator was required

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Author

E. DOTSIKA; E. KARAGOUNI; B. SUNDQUIST; B. MOREIN; A. MORGAN; M. VILLACRES-ERIKSSON

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0300-9475)

Published

1997

Language

EN

Field

Immunology and Microbiology (Life Sciences)