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Second-trimester Levels of Maternal Urinary Gonadotropin Peptide in Down Syndrome Pregnancy by Professor Jacob A. Canick; Leonard H. Kellner; Devereux N. Saller Jr; Glenn E. Palomaki; Roger P. Walker; Rapin Osathanondh is a Medicine article available to read on EtoBox.

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## Abstract Urinary gonadotropin peptide (UGP; β‐core fragment), a major metabolite of human chorionic gonadotropin (hCG), was shown recently to be markedly elevated in Down syndrome pregnancy between 19 and 22 weeks of gestation. To confirm and extend this finding, we obtained maternal urine and matching maternal serum samples from 14 cases of Down syndrome and six other aneuploidies between 17 and 21 weeks of gestation. UGP was measured in all these samples and in 91 singleton control urines. Results were corrected for urinary creatinine level and expressed as multiples of the control median (MOM). hCG levels were assayed in all serum samples from the cases and compared with previously established reference values. The median UGP level in Down syndrome cases was 5.34 MOM (range 2.71–12.57); 88 per cent of the values were above the 95th centile of control levels after modelling. The median maternal serum hCG level for the same cases was 2.20 MOM (range 0.84–3.40); 36 per cent of the values were above the 95th centile. The level of UGP in every case including all other aneuploidies was higher than the comparable maternal serum hCG level. Elevated UGP measurements are strongly assoc

Who reads Second-trimester Levels of Maternal Urinary Gonadotropin Peptide in Down Syndrome Pregnancy?

Author

Professor Jacob A. Canick; Leonard H. Kellner; Devereux N. Saller Jr; Glenn E. Palomaki; Roger P. Walker; Rapin Osathanondh

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0197-3851)

Published

1995

Language

EN

Field

Medicine (Health Sciences)