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This study introduces a new animal model to simulate the unloading and reloading of left ventricular assist devices (LVADs) to evaluate interventions aimed at preventing recurrent ventricular dysfunction. The model involved heterotopic heart transplantation in rats, where hearts were unloaded for two weeks and then reloaded, demonstrating significant changes in left ventricular pressures and volumes. The findings suggest that this model could facilitate research into adjunctive therapies, such as cell trans

Author

leroux.melanie.maria

Language

EN