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Recombinant Human Granulocyte-macrophage Colony-stimulating Factor Applied Locally in Low Doses Enhances Healing and Prevents Recurrence of Chronic Venous Ulcers by Erna Jaschke; August Zabernigg; Claus Gattringer is a Medicine article available to read on EtoBox.

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## Abstract Background Chronic venous leg ulcers have a major medical and economic impact on the elderly worldwide. Healing of the large ulcers (>10 cm^2^ ) occurs only in two‐thirds of the patients and reulceration of healed ulcers recurs in one‐third within 1 year. Because both healing and relapse rate influence greatly a patient’s quality of life and the overall cost of treatment, every effort should be made to improve these two parameters. Objective To determine the safety and efficacy of topical low‐dose recombinant human granulocyte‐macrophage colony‐stimulating factor (rhu GM‐CSF) for the treatment of venous ulcers, and to document any improvement in healing rates. Methods Thirty‐eight patients (29 women, 9 men; median age, 74 years) with chronic venous insufficiency were treated with topical rhu GM‐CSF (5 μg/mL 0.9% sodium chloride solution), followed by application of a compression dressing. All subjects were treated as outpatients. Results Complete healing was observed in 47 of the 52 ulcers (90.4%). The average healing time was 19 weeks. No systemic or local side‐effects from the therapy were observed. Nine chronic ulcers, previously refractory to conventional treatment

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Author

Erna Jaschke; August Zabernigg; Claus Gattringer

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0011-9059)

Published

1999

Language

EN

Field

Medicine (Health Sciences)