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Long-term Effects of Neonatal Alcohol Exposure on Photic Reentrainment and Phase-shifting Responses of the Activity Rhythm in Adult Rats by Gregg C. Allen; Yuhua Z. Farnell; Ji-ung Maeng; James R. West; Wei-Jung A. Chen; David J. Earnest is a Medicine article available to read on EtoBox.
What is Long-term Effects of Neonatal Alcohol Exposure on Photic Reentrainment and Phase-shifting Responses of the Activity Rhythm in Adult Rats about?
In rats, neonatal alcohol (EtOH) exposure coinciding with the period of rapid brain growth produces structural damage in some brain regions that often persists into adulthood and thus may have long-term consequences in the neural regulation of behavior. Because recent findings indicate that the circadian clock located in the rat suprachiasmatic nucleus is vulnerable to alcohol-induced insults during development, the present study examined the long-term effects of neonatal alcohol exposure on the photic regulation of circadian behavior in adult rats. Rat pups were exposed to alcohol (3.0, 4.5, or 6.0 g$kg 21 $day 21 ) or isocaloric milk formula on postnatal days 4-9 using artificial-rearing methods. At 2 months of age, animals were housed individually and circadian wheel-running behavior was continuously analyzed to determine the effects of neonatal alcohol treatment on the rate of reentrainment to a 6-h advance in the 12-h light:12-h dark photoperiod and the phase-shifting properties of free-running rhythms in response to discrete light pulses on a background of constant darkness. For all doses, neonatal alcohol exposure had a significant effect in reducing the time for reentrainme
Who reads Long-term Effects of Neonatal Alcohol Exposure on Photic Reentrainment and Phase-shifting Responses of the Activity Rhythm in Adult Rats?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Gregg C. Allen; Yuhua Z. Farnell; Ji-ung Maeng; James R. West; Wei-Jung A. Chen; David J. Earnest
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)