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Stat1-mediated Cytoplasmic Attenuation in Osteoimmunology by Hiroshi Takayanagi; Sunhwa Kim; Takako Koga; Tadatsugu Taniguchi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Stat1-mediated Cytoplasmic Attenuation in Osteoimmunology about?

Signal transducer and activator of transcription 1 (Stat1) is a critical mediator of gene transcription in type I interferon (IFN-a/b) signaling that is essential for host defense against viruses. In the skeletal system, type I IFNs (IFN-a/b) also play an important physiological role in the inhibition of receptor activator of NF-kB ligand (RANKL)-induced osteoclast differentiation and bone resorption: mice deficient in IFN signaling exhibit decreased bone mass accompanied by the activation of osteoclastogenesis. On the other hand, an unexpected increase in bone mass was observed in Stat1deficient mice, indicating that Stat1 has a hitherto unknown function in the regulation of bone formation. Indeed, Stat1 was found to have a unique, non-canonical function as a cytoplasmic attenuator of Runx2, a key transcription factor for osteoblast differentiation. Thus, the loss of Stat1 results in excessive activation of Runx2 and osteoblast differentiation, thereby tipping the balance in favor of bone formation over bone resorption. This is an interesting example in which a latent transcription factor attenuates the activity of another transcription factor in the cytoplasm, and reveals a novel

Who reads Stat1-mediated Cytoplasmic Attenuation in Osteoimmunology?

Author

Hiroshi Takayanagi; Sunhwa Kim; Takako Koga; Tadatsugu Taniguchi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)