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Gut Microbiome and Nonalcoholic Fatty Liver Disease by Meng-Yuan Wu; Jian-Gao Fan is a Medicine article available to read on EtoBox.

What is Gut Microbiome and Nonalcoholic Fatty Liver Disease about?

Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease globally and imposed a heavy economic burden on society and individuals. To date, the pathological process of NAFLD is not yet fully elucidated. Compelling evidences have demonstrated the pivotal role of gut microbiota in the pathogenesis of NAFLD, and gut dysbiosis has been commonly observed in patients with NAFLD. Gut dysbiosis impairs gut permeability, allowing the translocation of bacterial products such as lipopolysaccharides (LPS), short-chain fatty acids (SCFAs), and ethanol to the liver via portal blood flow. This review aimed to shed light on the underlying mechanisms by which gut microbiota influences the development and progression of NAFLD. In addition, the potential application of gut microbiome as a non-invasive diagnostic tool and a novel therapeutical target was reviewed.

Who reads Gut Microbiome and Nonalcoholic Fatty Liver Disease?

Author

Meng-Yuan Wu; Jian-Gao Fan

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)