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Can I read Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome on EtoBox?
Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome by Xiaonan Zhang; Zeping Wang; Xiaoya Li; Jiye Chen; Zongliang Yu; Xin Li; Changxin Sun; Lanqing Hu; Min Wu; Longtao Liu is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome about?
Ethnopharmacological relevance Polydatin is a bioactive ingredient extracted from the roots of the Reynoutria japonica Houtt, and it is a natural precursor of resveratrol. Polydatin is a useful inhibitor of inflammation and acts as a regulator of lipid metabolism. However, the specific mechanisms of action of polydatin in atherosclerosis (AS) remains poorly explained. Aim of the study The aim of this study was to assess the efficacy of polydatin on inflammation induced by the inflammatory cell death and autophagy in AS. Materials and methods Apolipoprotein E knockout (ApoE−/−) mice were fed with a high-fat diet (HFD) for 12 weeks to induce the formation of atherosclerotic lesions. The ApoE−/− mice were then randomly divided into the following six groups: (1) model group, (2) simvastatin group, (3) MCC950 group, (4) low dose polydatin group (Polydatin-L), (5) medium dose polydatin group (Polydatin-M), (6) and high dose polydatin group (Polydatin-H). The C57BL/6J mice were treated as controls and administered a standard chow diet. All mice were gavaged once daily for 8 weeks. The distribution of aortic plaques was observed by En Oil-red-O staining and hematoxylin and eosin staining (
Who reads Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Xiaonan Zhang; Zeping Wang; Xiaoya Li; Jiye Chen; Zongliang Yu; Xin Li; Changxin Sun; Lanqing Hu; Min Wu; Longtao Liu
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)