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What is Calpain about?

This study investigates the role of calpain, a Ca2+-dependent protease, in the a-processing of amyloid-b precursor protein (APP), which is crucial for understanding amyloid plaque formation in aging and senile dementia. The researchers found that overexpression of the l-calpain gene in HEK293 cells significantly increased calpain activity and APP secretion, particularly when stimulated by various agents. The findings suggest that calpain may be a viable candidate for a-secretase, warranting further investig

Author

thednasuper

Language

EN