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Sub-regional Anterior Cingulate Cortex Functional Connectivity Revealed Default Network Subsystem Dysfunction in Patients with Major Depressive Disorder by Peng, Xiaolong; Wu, Xiaoping; Gong, Ruxue; Yang, Rui; Wang, Xiang; Zhu, Wenzhen; Lin, Pan is a Medicine article available to read on EtoBox.

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## Abstract ## Background Major depressive disorder (MDD) is a prevalent mental disorder characterized by impairments in affect, behaviour and cognition. Previous studies have indicated that the anterior cingulate cortex (ACC) may play an essential role in the pathophysiology of depression. In this study, we systematically identified changes in functional connectivity (FC) for ACC subdivisions that manifest in MDD and further investigated the relationship between these changes and the clinical symptoms of depression. ## Methods Sub-regional ACC FC was estimated in 41 first-episode medication-naïve MDD patients compared to 43 healthy controls. The relationships between depressive symptom severity and aberrant FC of ACC subdivisions were investigated. In addition, we conducted a meta-analysis to generate the distributions of MDD-related abnormal regions from previously reported results and compared them to FC deficits revealed in this study. ## Results In MDD patients, the subgenual and perigenual ACC demonstrated decreased FC with the posterior regions of the default network (DN), including the posterior inferior parietal lobule and posterior cingulate cortex. FC of these regions wa

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Author

Peng, Xiaolong; Wu, Xiaoping; Gong, Ruxue; Yang, Rui; Wang, Xiang; Zhu, Wenzhen; Lin, Pan

Publisher

Cambridge University Press; Cambridge University Press (CUP) (ISSN 0033-2917)

Published

2020

Language

EN

Field

Medicine (Social Sciences)