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The ARCTIC REWIND trial assessed the long-term effects of tapering conventional synthetic disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis in sustained remission. Over three years, tapering strategies resulted in significantly higher rates of disease flare compared to stable-dose treatment, indicating that tapering may not be non-inferior to stable treatment. However, a notable subgroup of patients achieved drug-free remission, highlighting the importance of individualize

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billy10365

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EN