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Plasmacytoid Monocyte Proliferation Associated with Myeloproliferative Disorders by Fady K. Baddoura; Curtis Hanson; Wing C. Chan is a Medicine article available to read on EtoBox.

What is Plasmacytoid Monocyte Proliferation Associated with Myeloproliferative Disorders about?

Plasmacytoid T-cell (PTC) lymphoma is a rare clinicopathologic entity characterized by generalized lymphadenopathy in association with a myeloproliferative disorder. Hepatosplenomegaly and weight loss frequently are present. Nodal T-zone expansion by mononuclear cells with ultrastructural and immunohistochemical features typical of PTC is diagnostic. All of the five previously reported cases of PTC lymphoma coincided with or heralded the onset of a clinically aggressive myeloid leukemia. This strong association and recent immunohistochemical findings in reactive or neoplastic PTC favored a monocyte/macrophage derivation of these cells, and it has been suggested that they be renamed plasmacytoid monocytes (PM). Two additional cases of PTC lymphoma were studied at the institutions of the authors, and the findings supported the concept that PTC belong to the monocytic lineage. The disease presentation was generalized lymphadenopathy with constitutional symptoms. One patient also had hepatosplenomegaly and bilateral renal enlargement concomitantly with myelofibrosis with myeloid metaplasia that progressed within months to acute myelogenous leukemia. Similar rapid evolution of acute mon

Who reads Plasmacytoid Monocyte Proliferation Associated with Myeloproliferative Disorders?

Author

Fady K. Baddoura; Curtis Hanson; Wing C. Chan

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1992

Language

EN

Field

Medicine (Health Sciences)