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Can I read Substrate for the Myocardial Inflammation–Heart Failure Hypothesis Identified Using Novel USPIO Methodology on EtoBox?
Substrate for the Myocardial Inflammation–Heart Failure Hypothesis Identified Using Novel USPIO Methodology by Jakub Lagan; Josephine H. Naish; Kara Simpson; Min Zi; Elizabeth J. Cartwright; Phil Foden; Julie Morris; David Clark; Lindsay Birchall; Jessica Caldwell; Andrew Trafford; Christien Fortune; Michael Cullen; Nazia Chaudhuri; James Fildes; Jaydeep Sarma; Erik B. Schelbert; Matthias Schmitt; Karen Piper Hanley; Christopher A. Miller is a Medicine article available to read on EtoBox.
What is Substrate for the Myocardial Inflammation–Heart Failure Hypothesis Identified Using Novel USPIO Methodology about?
## Objectives: The purpose of this study was to identify where ultrasmall superparamagnetic particles of iron oxide (uspio) locate to in myocardium, develop a methodology that differentiates active macrophage uptake of uspio from passive tissue distribution; and investigate myocardial inflammation in cardiovascular diseases. ## Background: Myocardial inflammation is hypothesized to be a key pathophysiological mechanism of heart failure (hf), but human evidence is limited, partly because evaluation is challenging. uspio-magnetic resonance imaging (mri) potentially allows specific identification of myocardial inflammation but it remains unclear what the uspio-mri signal represents. ## Methods: Histological validation was performed using a murine acute myocardial infarction (mi) model. a multiparametric, multi-time-point mri methodology was developed, which was applied in patients with acute mi (n = 12), chronic ischemic cardiomyopathy (n = 7), myocarditis (n = 6), dilated cardiomyopathy (n = 5), and chronic sarcoidosis (n = 5). ## Results: Uspio were identified in myocardial macrophages and myocardial interstitium. r1 time-course reflected passive interstitial distribution whereas mu
Who reads Substrate for the Myocardial Inflammation–Heart Failure Hypothesis Identified Using Novel USPIO Methodology?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jakub Lagan; Josephine H. Naish; Kara Simpson; Min Zi; Elizabeth J. Cartwright; Phil Foden; Julie Morris; David Clark; Lindsay Birchall; Jessica Caldwell; Andrew Trafford; Christien Fortune; Michael Cullen; Nazia Chaudhuri; James Fildes; Jaydeep Sarma; Erik B. Schelbert; Matthias Schmitt; Karen Piper Hanley; Christopher A. Miller
- Publisher
- Elsevier ; Elsevier BV (ISSN 1936-878X)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)