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Fabrication of Multifunctional Mucoadhesive Buccal Patch for Drug Delivery Applications by Anahita Rohani Shirvan; Nahid Hemmatinejad; S. Hajir Bahrami; Azadeh Bashari is a Engineering article available to read on EtoBox.

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## Abstract Mucoadhesive buccal patch is a promising dosage form for a successful oral drug delivery, which provides unique advantages for various applications such as treatment of periodontal disease and postdental surgery disorders. The aim of this study is to synthesize a novel multifunctional mucoadhesive buccal patch in a multilayer reservoir design for therapeutic applications. The patches were fabricated through simultaneous electrospinning of chitosan/poly(vinylalcohol) (PVA)/ibuprofen and electrospraying of phenylalanine amino acid nanotubes (PhNTs) containing metronidazole into the electrospun mats through a layer‐by‐layer process. An electrospun poly(caprolactone) (PCL) was used as an impermeable backing layer to protect the mucoadhesive component from tongue movement and drug loss. Buccal patches were characterized using scanning electron microscopy (SEM) and field emission scanning electron microscopy (FESEM) and also evaluated in terms of physicomechanical parameters such as pH, weight, thickness, tensile strength, folding endurance, and mucoadhesive properties. The swelling index of the patches was examined with respect to the PVA/chitosan ratio. The effect of genipi

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Author

Anahita Rohani Shirvan; Nahid Hemmatinejad; S. Hajir Bahrami; Azadeh Bashari

Publisher

Wiley

Published

2021

Language

EN

Field

Engineering (Physical Sciences)