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Analog Regulation of Metabolic Demand by Nikolaus Sonnenschein; Marcel Geertz; Georgi Muskhelishvili; Marc-Thorsten Hütt is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Analog Regulation of Metabolic Demand about?

## Background The 3D structure of the chromosome of the model organism __Escherichia coli__ is one key component of its gene regulatory machinery. This type of regulation mediated by topological transitions of the chromosomal DNA can be thought of as an __analog__ control, complementing the __digital__ control, i.e. the network of regulation mediated by dedicated transcription factors. It is known that alterations in the superhelical density of chromosomal DNA lead to a rich pattern of differential expressed genes. Using a network approach, we analyze these expression changes for wild type __E. coli__ and mutants lacking nucleoid associated proteins (NAPs) from a metabolic and transcriptional regulatory network perspective. ## Results We find a significantly higher correspondence between gene expression and metabolism for the wild type expression changes compared to mutants in NAPs, indicating that supercoiling induces meaningful metabolic adjustments. As soon as the underlying regulatory machinery is impeded (as for the NAP mutants), this coherence between expression changes and the metabolic network is substantially reduced. This effect is even more pronounced, when we compute a

Who reads Analog Regulation of Metabolic Demand?

Author

Nikolaus Sonnenschein; Marcel Geertz; Georgi Muskhelishvili; Marc-Thorsten Hütt

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2006]-; Springer Science and Business Media LLC (ISSN 1752-0509)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)