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FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population by Haoran Wei; Mingming Zhao; Man Huang; Chenze Li; Jianing Gao; Ting Yu; Qi Zhang; Xiaoqing Shen; Liang Ji; Li Ni; Chunxia Zhao; Zeneng Wang; Erdan Dong; Lemin Zheng; Dao Wen Wang is a Medicine article available to read on EtoBox.
What is FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population about?
The association among plasma trimethylamine-N-oxide (TMAO), FMO3 polymorphisms, and chronic heart failure (CHF) remains to be elucidated. TMAO is a microbiota-dependent metabolite from dietary choline and carnitine. A prospective study was performed including 955 consecutively diagnosed CHF patients with reduced ejection fraction, with the longest follow-up of 7 years. The concentrations of plasma TMAO and its precursors, namely, choline and carnitine, were determined by liquid chromatography-mass spectrometry, and the FMO3 E158K polymorphisms (rs2266782) were genotyped. The top tertile of plasma TMAO was associated with a significant increment in hazard ratio (HR) for the composite outcome of cardiovascular death or heart transplantation (HR = 1.47, 95% CI = 1.13-1.91, P = 0.004) compared with the lowest tertile. After adjustments of the potential confounders, higher TMAO could still be used to predict the risk of the primary endpoint (adjusted HR = 1.33, 95% CI = 1.01-1.74, P = 0.039). This result was also obtained after further adjustment for carnitine (adjusted HR = 1.33, 95% CI = 1.01-1.74, P = 0.039). The FMO3 rs2266782 polymorphism was associated with the plasma TMAO concent
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- Author
- Haoran Wei; Mingming Zhao; Man Huang; Chenze Li; Jianing Gao; Ting Yu; Qi Zhang; Xiaoqing Shen; Liang Ji; Li Ni; Chunxia Zhao; Zeneng Wang; Erdan Dong; Lemin Zheng; Dao Wen Wang
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)