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Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C by Hisayuki Hamada; Hiroshi Yatsuhashi; Koji Yano; Manabu Daikoku; Kokichi Arisawa; Osami Inoue; Michiaki Koga; Keisuke Nakata; Katsumi Eguchi; Michitami Yano is a Medicine article available to read on EtoBox.
What is Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C about?
## Abstract ## BACKGROUND Hepatitis C virus (HCV) infection is a heterogeneous disease, the natural history of which remains controversial. There is solid evidence that chronic HCV infection is responsible for the occurrence of hepatocellular carcinoma (HCC). The aim of the current cohort study was to determine the rate of the development of HCC from the time of primary HCV infection and to assess the risk factors for the development of HCC in chronic posttransfusion hepatitis C patients. ## METHODS Four hundred sixty‐nine patients with clinically compensated HCV, who had undergone a single blood transfusion comprised the current study cohort. Patients with other risk factors for chronic liver disease were excluded. All patients were referred to the liver center at the National Nagasaki Medical Center between December 1980 and December 1998 and were followed prospectively until the end of the analysis (June 2000). ## RESULTS Follow‐up data were obtained for 445 patients. The mean duration from HCV infection to the end of the observation was 28 years. Fifty‐two patients (11.1%) progressed to HCC. The mean duration from the time of blood transfusion to the diagnosis of HCC was 31 yea
Who reads Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C?
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- Author
- Hisayuki Hamada; Hiroshi Yatsuhashi; Koji Yano; Manabu Daikoku; Kokichi Arisawa; Osami Inoue; Michiaki Koga; Keisuke Nakata; Katsumi Eguchi; Michitami Yano
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)