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Sepsis: Understanding Its Complex Pathogenesis by Veronica Nefiru is a document available to read on EtoBox.
What is Sepsis: Understanding Its Complex Pathogenesis about?
1) Sepsis is a systemic response to severe infection that is mediated by macrophage-derived cytokines targeting end organs. It is a leading cause of death in ICUs. 2) Early clinical trials of drugs targeting the proinflammatory phase of sepsis failed to show efficacy. This suggests our understanding of the pathophysiology was incomplete. 3) The document proposes adding compensatory anti-inflammatory response syndrome (CARS) and mixed antagonists response syndrome (MARS) to the existing definitions to bet
- Author
- Veronica Nefiru
- Language
- EN