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Diagnostic Utility of INSM1 in Medullary Thyroid Carcinoma by Jae Yeon Seok; Myunghee Kang; Mariza De Peralta-Venturina; Xuemo Fan is a Medicine article available to read on EtoBox.

What is Diagnostic Utility of INSM1 in Medullary Thyroid Carcinoma about?

Insulinoma-associated protein 1 (INSM1) is shown to be an excellent marker for neuroendocrine differentiation. However, the diagnostic utility of INSM1 in medullary thyroid carcinoma (MTC) has not yet been extensively investigated. INSM1 staining was performed on 21 MTCs, 7 MTC mimickers (including 3 papillary carcinomas, 2 poorly differentiated carcinomas, 1 follicular adenoma, and 1 nodular plasma cell hyperplasia), and 3 cases of C-cell hyperplasia. INSM1 staining of these cases was compared with the traditional MTC markers including calcitonin (CT), monoclonal carcinoembryonic antigen (mCEA), chromogranin A (CgA), and synaptophysin (Syn). The H-score was generated using the QuPath program, an open-source image analysis software. All 21 MTC cases and 3 C-cell hyperplasia cases were positive for all markers. The MTC mimickers were entirely negative for INSM1. INSM1 and Syn displayed, more consistently, high expression with minimal variability than CgA that showed a wide range of expression with significant variability. mCEA and CT exhibited mostly a high expression with some variability. Being a nuclear stain, interpretation was easier with INSM1 compared to other cytoplasmic mar

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Author

Jae Yeon Seok; Myunghee Kang; Mariza De Peralta-Venturina; Xuemo Fan

Publisher

SAGE Publications

Published

2021

Language

EN

Field

Medicine (Health Sciences)