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Immunolocalization of cathepsin D in pneumocytes of normal human lung and in pulmonary fibrosis by M. Kasper; M. Haase; D. Schuh; M. Müller; P. Lackie is a Medicine article available to read on EtoBox.

What is Immunolocalization of cathepsin D in pneumocytes of normal human lung and in pulmonary fibrosis about?

Cathepsin D expression has been assessed by immunohistochemistry and immunoelectron microscopy in fetal, normal adult and injured lungs of human beings. In addition to the well known positivity of alveolar macrophages and the bronchial epithelial cells, normal type I and to a lesser extent type II pneumocytes showed a granular, cytoplasmic staining pattern. Using immunogold labelling of lowicryl embedded human lung, cathepsin D was present in lysosomes of epithelial cells. Double immunofluorescence labelling employing type I and type II specific antibodies or lectins confirmed the epithelial staining for cathepsin D. At the terminal sac period during lung development cathepsin D appears in the alveolar epithelium. In fibrotic specimens, enhanced immunoreactivity was found in epithelial and non-epithelial cells. Proliferative epithelial formations were strongly stained with cathepsin D antibodies, whereas detached, desquamated epithelial cells were weakly positive or negative. We suggest that cathepsin D plays a role in the remodelling process during fibrogenesis.

Who reads Immunolocalization of cathepsin D in pneumocytes of normal human lung and in pulmonary fibrosis?

Author

M. Kasper; M. Haase; D. Schuh; M. Müller; P. Lackie

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1432-2307)

Published

1996

Language

EN

Field

Medicine (Health Sciences)