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Long-term Potentiation in Bone – a Role for Glutamate in Strain-induced Cellular Memory? by Gary J Spencer; Paul G Genever is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background: The adaptive response of bone cells to mechanical strain is a primary determinant of skeletal architecture and bone mass. in vivo mechanical loading induces new bone formation and increases bone mineral density whereas disuse, immobilisation and weightlessness induce bone loss. the potency of mechanical strain is such that a single brief period of loading at physiological strain magnitude is able to induce a long-lasting osteogenic response that lasts for days. although the process of mechanotransduction in bone is incompletely understood, observations that responses to mechanical strain outlast the duration of stimulation necessitate the existence of a form of cellular memory through which transient strain episodes are recorded, interpreted and remembered by bone cells. recent evidence supports the existence of a complex multicellular glutamate-signalling network in bone that shares functional similarities to glutamatergic neurotransmission in the central nervous system. in neurones, these signalling molecules coordinate synaptic communication required to support learning and memory formation, through a complex process of long-term potentiation. ## Presentation of t

Who reads Long-term Potentiation in Bone – a Role for Glutamate in Strain-induced Cellular Memory??

Author

Gary J Spencer; Paul G Genever

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2000]-2018.; Springer Science and Business Media LLC (ISSN 1471-2121)

Published

2003

Language

EN

ISBN

9781471212147

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)