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Evaluation of Vasodilatory Effect and Antihypertensive Effect of Chrysin Through in Vitro and Sub-chronic in Vivo Study by Wan Yin Tew; Chu Shan Tan; Chong Seng Yan; Hui Wei Loh; Xu Wen; Xu Wei; Mun Fei Yam is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Chrysin, a bioflavonoid belonging to the flavone, occurs naturally in plants such as the passionflower, honey and propolis. Few studies have demonstrated that chrysin can promote vasorelaxant activities in rats' aorta and mesenteric arteries. To date, no research has explored the signalling system routes that chrysin may utilise to produce its vasorelaxant action. Therefore, this study aimed to investigate the underlying mechanisms involved in chrysin-induced vasorelaxant in rats' aortic rings and assess the antihypertensive effect of chrysin in spontaneously hypertensive rats (SHRs). The findings revealed that chrysin utilised both endothelium-dependent and endothelium-independent mechanisms. The presence of L-NAME (endothelial NO synthase inhibitor), ODQ (sGC inhibitor), methylene blue (cGMP lowering agent), 4-AP (voltage-gated potassium channel inhibitor), atropine (muscarinic receptors inhibitor) and propranolol (β-adrenergic receptors inhibitor) significantly reduced the chrysin's vasorelaxant action. Furthermore, chrysin can reduce intracellular Ca2+ levels by limiting the extracellular intake of Ca2+ through voltage-operated calcium channels and blocking the intracellular re

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Author

Wan Yin Tew; Chu Shan Tan; Chong Seng Yan; Hui Wei Loh; Xu Wen; Xu Wei; Mun Fei Yam

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)