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Exercise-induced pulmonary hypertension in HFpEF and HFrEF: Different pathophysiologic mechanism behind similar functional impairment by Nicola Riccardo Pugliese; Matteo Mazzola; Rosalinda Madonna; Luna Gargani; Nicolò De Biase; Frank L. Dini; Stefano Taddei; Raffale De Caterina; Stefano Masi is a Medicine article available to read on EtoBox.

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## Aims: Pathophysiological mechanisms behind cardio-pulmonary impairment in heart failure (hf) with reduced (hfref) and preserved (hfpef) ejection fraction are likely different. we analysed them using combined cardiopulmonary-exercise stress echocardiography (cpet-ese). ## Methods: We matched 1:1 subjects with hfref (n = 90) and hfpef (n = 90) for age, sex, body mass index (bmi), peak oxygen consumption, and minute ventilation/carbon dioxide production slope. all patients underwent a symptom-limited graded ramp bicycle cpet-ese compared with 40 age-, sex- and bmi-matched healthy controls. ## Results: During a median follow-up of 25 months, we observed 22 deaths and 80 hf hospitalisations, with similar distribution between hfpef and hfref. compared with hfref, hfpef had a higher prevalence of metabolic syndrome (p = 0.02) with higher levels of high-sensitivity c-reactive protein and uric acid (p < 0.01). the multipoint mean pulmonary artery pressure/cardiac output (mpap/co) slope showed equally increased values in hfref and hfpef (3.5 ± 1.8 and 3.7 ± 1.5 mmhg/l/min) compared with controls (1.8 ± 1.1 mmhg/l/min; p < 0.0001). during exercise, hfpef displayed more adverse interaction

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Author

Nicola Riccardo Pugliese; Matteo Mazzola; Rosalinda Madonna; Luna Gargani; Nicolò De Biase; Frank L. Dini; Stefano Taddei; Raffale De Caterina; Stefano Masi

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)