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Temporal evolution of MR perfusion in neonatal hypoxic‐ischemic encephalopathy by Pia Wintermark; Adrien C. Moessinger; François Gudinchet; Reto Meuli is a Medicine article available to read on EtoBox.

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## Abstract ## Purpose To illustrate the evolution of brain perfusion‐weighted magnetic resonance imaging (PWI‐MRI) in severe neonatal hypoxic‐ischemic (HI) encephalopathy, and its possible relation to further neurodevelopmental outcome. ## Materials and Methods Two term neonates with HI encephalopathy underwent an early and a late MRI, including PWI. They were followed until eight months of age. A total of three “normal controls” were also included. Perfusion maps were obtained, and relative cerebral blood flow (rCBF) and cerebral blood volume (rCBV) values were measured. ## Results Compared to normal neonates, a hyperperfusion (increased rCBF and rCBV) was present on early scans in the whole brain. On late scans, hyperperfusion persisted in cortical gray matter (normalization of rCBF and rCBV ratios in white matter and basal ganglia, but not in cortical gray matter). Diffusion‐weighted imaging (DWI) was normalized, and extensive lesions became visible on T2‐weighted images. Both patients displayed very abnormal outcome: Patient 2 with the more abnormal early and late hyperperfusion being the worst. ## Conclusion PWI in HI encephalopathy did not have the same temporal evolution as

Who reads Temporal evolution of MR perfusion in neonatal hypoxic‐ischemic encephalopathy?

Author

Pia Wintermark; Adrien C. Moessinger; François Gudinchet; Reto Meuli

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

2008

Language

EN

Field

Medicine (Health Sciences)