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Can I read Prognostic factors of BRAF V600E colorectal cancer with liver metastases: a retrospective multicentric study on EtoBox?
Prognostic factors of BRAF V600E colorectal cancer with liver metastases: a retrospective multicentric study by Sahir Javed; Stéphane Benoist; Patrick Devos; Stéphanie Truant; Rosine Guimbaud; Astrid Lièvre; David Sefrioui; Romain Cohen; Pascal Artru; Aurélien Dupré; Jean-Baptiste Bachet; Christelle de la Fouchardière; Anne Ploquin; Anthony Turpin is a Medicine article available to read on EtoBox.
What is Prognostic factors of BRAF V600E colorectal cancer with liver metastases: a retrospective multicentric study about?
## Background __BRAF__ V600E-mutant colorectal cancers (CRCs) are associated with shorter survival than __BRAF__ wild-type tumors. Therapeutic decision-making for colorectal liver metastases (CRLM) harboring this mutation remains difficult due to the scarce literature. The aim was to study a large cohort of __BRAF__ V600E-mutant CRLM patients in order to see if surgery extend overall survival among others prognostic factors. ## Methods __BRAF__ V600E-mutant CRCs diagnosed with liver-only metastases, resected or not, were retrospectively identified between April 2008 and December 2017, in 25 French centers. Clinical, molecular, pathological characteristics and treatment features were collected. Overall survival (OS) was defined as the time from CRLM diagnosis to death from any cause. Cox proportional hazard models were used for statistical analysis. ## Results Among the 105 patients included, 79 (75%) received chemotherapy, 18 (17%) underwent upfront CRLM surgery, and 8 (8%) received exclusive best supportive care. CRLM surgery was performed in 49 (46.7%) patients. CRLM were mainly synchronous (90%) with bilobar presentation (61%). The median OS was 34 months (range, 28.9–67.3 month
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- Author
- Sahir Javed; Stéphane Benoist; Patrick Devos; Stéphanie Truant; Rosine Guimbaud; Astrid Lièvre; David Sefrioui; Romain Cohen; Pascal Artru; Aurélien Dupré; Jean-Baptiste Bachet; Christelle de la Fouchardière; Anne Ploquin; Anthony Turpin
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)