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Lenvatinib DDI with Schisantherin A/Sandrin A by Sai HS Boddu is a document available to read on EtoBox.

What is Lenvatinib DDI with Schisantherin A/Sandrin A about?

This study developed a physiologically-based pharmacokinetic (PBPK) model to evaluate drug-drug interactions (DDIs) between lenvatinib and the traditional Chinese medicinal compounds schisantherin A (STA) and schisandrin A (SIA), which are CYP3A4 inhibitors. The model predicted slight increases in lenvatinib exposure when co-administered with STA/SIA, suggesting minimal pharmacokinetic changes but potential enhancement of efficacy. The findings provide clinically relevant insights into the safety of concurr

Author

Sai HS Boddu

Language

EN